世界針灸學會聯合會

電針對完全弗氏佐劑實驗鼠鎮痛作用的整合分析

作者:趙雪、陳波 來源:世界針灸雜志 點擊:771次 更新:2019-10-08
  

The analgesic effect of electroacupuncture in complete freund's adjuvant rats—a meta analysis☆

電針對完全弗氏佐劑實驗鼠鎮痛作用的整合分析


Kuo ZHANG(張闊)a, Zhi-fang XU(徐枝芳)b,c, Kai LI(李凱)d, Xue ZHAO(趙雪)b*, Bo CHEN(陳波)c*, Yi GUO(郭義)b,e, Shen-jun WANG (王慎軍)b,c

a Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, China(天津大學醫學工程與轉化醫學研究院,天津300072,中國)

b Experimental Acupuncture-Moxibustion Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China (天津中醫藥大學實驗針灸學研究中心,天津301617,中國)

c Acu-moxibustion and Tuina Department, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China (天津中醫藥大學針灸推拿學院,天津301617,中國)

d Department of Gynaecology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300381, China(天津中醫藥大學第一附屬醫院婦科,天津300381,中國)

e College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese

Medicine, Tianjin, 301617,China(天津中醫藥大學中醫學院,天津301617,中國)


☆Supported by the National Natural Science Foundation of China: 81330088, 81303025.

? Corresponding author.


E-mail address: [email protected] (Xue ZHAO)

[email protected] (Bo CHEN).


Abstract


Pain is a global problem and has been found sensitive to acupuncture. A large number of existing and newly published studies have demonstrated the analgesic effect of electroacupuncture (EA) in complete Freund’s adjuvant (CFA) rat model, necessitating a new and comprehensive review. To evaluate the curative effect of EA on thermal hyperalgesia in CFA rats, and to explore parameters that influence treatment effects, studies of EA treatment on thermal hyperalgesia of CFA rat model were identified from nine databases up to June 17, 2017. Outcome measure was heat pain threshold. All the data were analyzed using Stata 14.0/MP software. 26 studies identified included 801 rats. The quality score of the studies ranged from 3 to 6, with a mean of 4.08. The effect of EA group was improvement in outcome compared with CFA group. In subgroup analyses, frequency 2, 100, 2/100 or 20-100 Hz, acupoint Huántiào (環跳GB30),Kūnlún(昆侖  BL60)+Xuánzhōng (懸鐘 GB39), Zúsānl? (足三里 ST36)+BL60 or ST36+Sānyīnjiāo(三陰交SP6), retention time 20 or 30min, treatment time for post-CFA injection immediately, the same day as CFA injection, post-CFA injection 24 or 48h and interval 24 or 48h all can improve the effect on CFA rat heat pain threshold. These results show that there is positive effective of EA in CFA-induced pain, different parameters have different effects on EA treatment of CFA heat hyperalgesia, however, because of the number of eligible researches and the high risk of bias, the evidence supporting this conclusion is limited.


Key Words: electroacupuncture (EA), analgesia, complete Freund’s adjuvant, rats


[摘 要]疼痛是一個全球性問題,人們發現它對針灸很敏感。大量現有和新發表的研究證明了電針(EA)在完整的弗氏佐劑(CFA)實驗鼠模型中的鎮痛作用,因此有必要進行新的全面綜述。為評估電針對弗氏佐劑實驗鼠熱痛覺過敏的療效,并探討影響治療效果的參數,截至2017年6月17日,我們從9個數據庫中確定了電針治療對弗氏佐劑實驗鼠熱痛覺過敏的研究。結果測量為熱痛閾值。所有數據均采用Stata 14.0/MP軟件進行分析。26項研究包括801只實驗鼠。研究的質量分數為3至6分,平均為4.08分。與弗氏佐劑組相比,電針組的效果是預后的改善。在亞組分析中,頻率2、100、2 / 100或20-100 Hz,穴位環跳GB30,昆侖BL60)+Xuánzhōng(懸鐘GB39,足三里ST36+ BL60或ST36 +三陰交SP6,保留時間20或30min,立即注射弗氏佐劑,弗氏佐劑注射當天,注射后24或48小時和間隔24或48小時的治療時間均可以改善對弗氏佐劑實驗鼠熱痛的作用閾。這些結果表明,電針在弗氏佐劑誘發的疼痛中具有積極的療效,不同的參數對電針治療弗氏佐劑熱痛覺過敏的效果不同,但由于符合條件的研究數量較多,且存在較高的偏倚風險,支持這一結論的證據有限。


[關鍵詞]電針(EA);鎮痛;完全弗氏佐劑;實驗鼠

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